XI. Overall Regulation of Fatty Acid Metabolism
Oxidation is regulated at several levels, but primarily by substrate
availability, which in turn is controlled hormonally.
- Hormone sensitive lipase in adipose tissue is activated by
phosphorylation (glucagon). Its activity is low when insulin
levels are high.
- High levels of malonyl CoA allosterically inhibit CAT-I. This
prevents beta-oxidation during fatty acid synthesis.
- CoA must be available for beta-oxidation to proceed, since it is
a substrate for the thiolase reaction.