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II. Acetyl CoA -- The Center of Lipid Metabolism

Overview of Acetyl CoA Metabolism Precursors of Acetyl CoA Products of Acetyl CoA Metabolism Structure of Acetyl CoA Function of CoA     Previous Page Next Page

Function of CoA

CoA is a commonly used carrier for activated acyl groups (acetyl, fatty acyl and others). The thioester bond which links the acyl group to CoA has a large negative standard free energy of hydrolysis (-7.5 kcal/mole). This qualifies it as a high energy bond, and explains why an acyl group attached to CoA in this manner is considered to be activated.


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