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II. Acetyl CoA -- The Center of Lipid Metabolism

    

Function of CoA

CoA is a commonly used carrier for activated acyl groups (acetyl, fatty acyl and others). The thioester bond which links the acyl group to CoA has a large negative standard free energy of hydrolysis (-7.5 kcal/mole). This qualifies it as a high energy bond, and explains why an acyl group attached to CoA in this manner is considered to be activated.