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VI. Modification of Dietary and Endogenous Fatty Acids

Overview     Elongation Elongation: Fatty Acid Synthesis in the Endoplasmic Reticulum Elongation: Mitochondrial Fatty Acid Elongation, a Minor Pathway     Desaturation Desaturation: The Overall Reaction Desaturation: Specificity     Previous Page Next Page

Elongation: Mitochondrial Fatty Acid Elongation, a Minor Pathway

In the mitochondria fatty acid elongation occurs by a reversal of beta-oxidation.

Mito. FA Elong.

This shows the overall reaction of fatty acid elongation in mitochondria. The process is essentially a reversal of beta-oxidation, except that one NADPH and one NADH are required (beta-oxidation yields two NADH). Mitochondrial fatty acid elongation acts primarily on fatty acyl CoA substrates shorter than 16 carbons.

Notice that here acetyl CoA is the source of the added carbons.

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