Fatty Acids Home  |   Outline  |   FAQ  |   Search  |   Feedback

IX. Mitochondrial beta-oxidation

Overview     Four enzymes and reactions Four enzymes and reactions: Dehydrogenation Four enzymes and reactions: Hydration Four enzymes and reactions: 2nd dehydrogenation Four enzymes and reactions: Thiolytic cleavage     Complete beta-oxidation of palmitoyl CoA     Additional Enzymes Additional Enzymes: Enoyl CoA Additional Enzymes: trans- vs cis Additional Enzymes: Propionyl CoA     Summary     Previous Page Next Page

Four enzymes and reactions: Thiolytic cleavage

Thiolytic cleavage of the thioester is catalyzed by beta-ketoacyl CoA thiolase.


The shortened fatty acyl group is now ready for another round of beta-oxidation. After the fatty acyl CoA has been reduced to acetyl or propionyl CoA, beta-oxidation is complete.

Beta-oxidation is regulated as a whole primarily by fatty acid availability; once fatty acids are in the mitochondria they are oxidized as long as there is adequate NAD+ and CoA.


Previous Page Next Page