IX. Mitochondrial beta-oxidation
Additional Enzymes: Enoyl CoA
The action of enoyl CoA isomerase is required to handle double bonds at odd-numbered carbons because beta-oxidation generates or requires pre-existing double bonds at even-numbered carbons.
- If there is a double bond at an odd-numbered carbon (e.g.,
18:1 9), the action of
enoyl CoA isomerase is required to
move the naturally occurring cis- bond and convert it to the
trans- bond used in beta-oxidation.
- The product, with a trans- double bond, is a substrate for
enoyl CoA hydratase, the second enzyme of beta-oxidation.