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IX. Mitochondrial beta-oxidation

Overview     Four enzymes and reactions Four enzymes and reactions: Dehydrogenation Four enzymes and reactions: Hydration Four enzymes and reactions: 2nd dehydrogenation Four enzymes and reactions: Thiolytic cleavage     Complete beta-oxidation of palmitoyl CoA     Additional Enzymes Additional Enzymes: Enoyl CoA Additional Enzymes: trans- vs cis Additional Enzymes: Propionyl CoA     Summary     Previous Page Next Page

Additional Enzymes: trans- vs cis

Generating a trans- instead of a cis- double bond.

If there is also a double bond at an even-numbered carbon (e.g., the second double bond in 18:2 Delta9,12), the problem is to generate a trans- double bond instead of a cis-. This occurs in an indirect manner. Both activities occur in the mitochondrial matrix.

Two double bonds
Wrong trans- bond
Double bond isomerization


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