Question 8 of 16

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IThe formation of dATP for DNA synthesis occurs primarily by:

A. de novo synthsis beginning with dPRPP.

B. salvaging using A-PRT.

C. salvaging adenine using a nucleoside phosphorylase and dR 1-P.

D. converting ADP to dADP using thioredoxin.

E. converting dIMP to dAMP using 5,10-methylene THF.

Comments:

A. De novo synthesis occurs with PRPP only.

B. Very little adenine is salvaged.

C. See above. What adenine is salvaged would be by PRT since the phosphorylase is used primarily for pyrimidines.

D. Correct. The resulting dADP would be converted to the triphophate by a nucleoside diphosphate kinase.

E. That pathway converts dUMP to dTMP.

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Last modified 1/5/95