Question 8 of 16
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IThe formation of dATP for DNA synthesis occurs primarily by:
The correct answer is (D).
- A. de novo synthsis beginning with dPRPP.
- B. salvaging using A-PRT.
- C. salvaging adenine using a nucleoside phosphorylase and dR 1-P.
- D. converting ADP to dADP using thioredoxin.
- E. converting dIMP to dAMP using 5,10-methylene THF.
- A. De novo synthesis occurs with PRPP only.
- B. Very little adenine is salvaged.
- C. See above. What adenine is salvaged would be by PRT since the phosphorylase is used primarily for pyrimidines.
- D. Correct. The resulting dADP would be converted to the triphophate by a nucleoside diphosphate kinase.
- E. That pathway converts dUMP to dTMP.
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Last modified 1/5/95