Seen here in white matter is a large "plaques" of demyelination in a predominantly periventricular location. The plaques have a grey-tan appearance, instead of the white of unaffected white matter. Such plaques are typical for multiple sclerosis (MS). These plaques lead to the clinical appearance of transient or progressive loss of neurological function. Since the disease is multifocal and the lesions appear over time, the clinical findings can be quite varied.