On microscopic examination at high magnification the granulomatous nature of the inflammation of Crohn disease is demonstrated here with epithelioid cells, giant cells, and many lymphocytes. Special stains for organisms are negative.

The clinical manifestations of CD are variable and can include diarrhea, fever, and pain, as well as extraintestinal manifestations of arthritis, uveitis, erythema nodosum, and ankylosing spondylitis.