Electron Microscopy

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The following grayscale electron micrographic images are available [file sizes average 100 to 160k]:

Normal Structures

StructureDescription
NeutrophilNormal polymorphonuclear leukocyte
LymphocyteNormal lymphocyte
Plasma cellNormal plasma cell with prominent cytoplasmic smooth endoplasmic reticulum
MacrophageNormal macrophage with oblong nucleus, nucleolus, and cytoplasm with a variety of inclusions
PlateletsNormal platelets
MitochondriaHappy mitochondria within a cell
Skeletal muscleNormal skeletal muscle, normal (inset shows a single sarcomere with dark Z discs, and a central M line, with thin actin and thick myosin filaments)
CollagenNormal collagen fibrils
CiliaNormal cilia of respiratory tract epithelium


Miscellaneous Findings

StructureDescription
AmyloidAmyloid fibrils, with inset demonstrating array of fibrils
AdrenoleukodystrophyAdrenoleukodystrophy, adrenal gland, with long parallel inclusions of long chain fatty acids
Birbeck granulesBirbeck granules (inset shows several at higher magnification) from a case of histiocytosis X
Histiocytosis XCell with a clefted nucleus from a case of histiocytosis X
BacteriaPseudomonas bacteria
CryptosporidiaCryptosporidia along small intestinal brush border
Herpes simplex virusHerpes simplex virus in brain, viral particles (inset) in nucleus
JC papovavirusProgressive multifocal leukoencephalopathy (PML) with JC virus in brain, small round dark viral particles in nucleus
HIV-1Human immunodeficiency virus, viral particles at low magnification adjacent to cell surface
HIV-1Human immunodeficiency virus, viral particles at medium magnification
HIV-1Human immunodeficiency virus, viral particle budding from cell surface at top, and complete viral particle at bottom, high magnification
Inclusion body myositisSkeletal muscle with inclusion body myositis
Nemaline myopathySkeletal muscle with nemaline rods
Ciliary dyskinesisRespiratory tract cilia lacking dynein arms


Neoplasms

StructureDescription
AdenocarcinomaAdenocarcinoma with several features typical of a neoplasm of epithelial origin, including a junctional complex (tight junction at asterisk, desmonsomes at crosses, and a mucin granule M) and lumenal microvilli at the upper right
Junctional complex Junctional complex, higher magnification, with tight junction at right and desmosomes at left
Squamous cell carcinomaSquamous cell carcinoma with many desomosomes and cytoplasmic tonofilaments streaming to the left
MicrovilliMicrovilli seen in cell from adenocarcinoma of the colon (inset shows the dense core rootlets below and the rounded glycocalyceal bodies in the villi above
Intracytoplasmic lumenIntracytoplasmic lumen in a cell from metastatic carcinoma of breast
LeiomyosarcomaLeiomyosarcoma demonstrating cytoplasmic filaments with condensations to the left of the nucleus, a lipid body at the far left, and subplasmalemmal filament condensations and pinocytotic vesicles near nucleus at the right (also seen in the inset)
MesotheliomaMesothelioma of pleura with long, curved microvilli
Ewing's sarcomaEwing's sarcoma of bone with extensive cytoplasmic glycogen deposits
PremelanosomesPremelanosomes from a malignant melanoma, composite of two cases
MelanosomesMelanosomes (inset shows the dark oblong melanosomes in more detail) from a malignant melanoma
Adrenal carcinomaLarge mitochondria with tubular cristae above normal mitochondria in a cell from adrenal cortical carcinoma
Neurosecretory granulesNeurosecretory granules (some with a thin surrounding halo) in a neuroendocrine neoplasm


Renal Lesions

StructureDescription
Minimal change diseaseMinimal change disease (MCD) with effacement of podocyte foot processes
Post-streptococcal glomerulonephritisPost-streptococcal glomerulonephritis with hypercellularity
Membranous nephropathyMembranous nephropathy with thickened glomerular basement membrane containing electron dense deposits
Lupus nephritis"Fingerprint" with lupus nephritis
Membranoproliferative glomerulonephritis, type IMembranoproliferative glomerulonephritis, type I with splitting and reduplication of basement membrane
Dense deposit diseaseDense deposit disease with dense deposits

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