Premature and/or prolonged rupture of fetal membranes (PROM) increases the risk for intrauterine infection, because bacteria can pass into the normally sealed amniotic cavity. This leads to acute inflammation as seen here above and below as an acute chorioamnionitis within the fetal membranes. Note the numerous neutrophils. The fetus may subsequently become infected and suffer intrauterine fetal demise. Also, the inflammation may lead to premature labor and premature birth.