This is IgA nephropathy, and the immunofluorescence pattern demonstrates positivity with antibody to IgA. Note that the pattern is that of mesangial deposition in the glomerulus.

Some viruses and bacteria express N-acetylgalactosamine on their cell surfaces so that infection may promote anti-glycan antibody formation. IgA nephropathy may initially appear in association with an upper respiratory or gastrointestinal infection.

Some of these patients progress slowly to chronic renal failure.

Early in the course, there may be gross hematuria, often within 3 days following a respiratory tract infection.



Macroscopic Urinalysis:

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Leukocyte esterase
Nitrite
pH
Protein
Blood
Specific gravity
Ketones
Glucose
Bilirubin
CharacteristicResult
ColorYellow
AppearanceCloudy
Leukocyte EsteraseNeg
NitriteNeg
pH6.5
Protein1+
Blood3+
Specific Gravity1.020
KetonesNeg
GlucoseNeg
BilirubinNeg

Microscopic Urinalysis:

CharacteristicResult
WBC/hpf <5/hpf
RBC/hpf 100-200/hpf
Casts Few hyaline, RBC, granular casts
OtherDysmorphic RBCs