This is IgA nephropathy, and the immunofluorescence pattern demonstrates positivity with antibody to IgA. Note that the pattern is that of mesangial deposition in the glomerulus.
Some viruses and bacteria express N-acetylgalactosamine on their cell surfaces so that infection may promote anti-glycan antibody formation. IgA nephropathy may initially appear in association with an upper respiratory or gastrointestinal infection.
Some of these patients progress slowly to chronic renal failure.
Early in the course, there may be gross hematuria, often within 3 days following a respiratory tract infection.
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|Casts||Few hyaline, RBC, granular casts|