This is the low power microscopic appearance of an angiomylolipoma. There is normal renal parenchyma at the left. The tumor has a strip of adipose tissue (the "lipoma" part) that then blends in with interlacing bundles of smooth muscle (the "myo" component) in which are scattered vascular spaces (the "angio" component).


What gene mutation is most likely present in both sporadic and inherited forms of angiomyolipoma?

A PKD-1

B TSC-2

C VHL

C WT-1