Glomerular disease with systemic lupus erythematosus (SLE) is common, and lupus nephritis can have many morphologic manifestations as seen on renal biopsy. In general, the more immune complex deposition and the more cellular proliferation, the worse the disease. In this case, there is extensive immune complex deposition in the thickened glomerular capillary loops, giving a so-called wire loop appearance.
Characteristic urinalysis findings are shown below.
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|Casts||Many hyaline, WBC, RBC, granular casts|
|Other||Mucus, renal tubular cells|