Notes
Outline
Slide 1
Opening access to medical research—an insider’s view on the changes in scientific publishing
Barbara Cohen, PhD
Senior Editor, Public Library of Science
University of Utah
7 October 2004
Today’s circulation-based publishing model
STM publishing is BIG business
$ 9 billion/year
6,000 journal titles
740 articles per day (270,000/year)
Publishers
Commercial: Elsevier, Springer, Wiley, Blackwell
University Presses: OUP, RUP
Societies: IEEE, ASCI
Things are getting worse: the  journals crisis
What is the Public Library of Science?
A nonprofit organization of scientists committed to making the world’s scientific and medical literature a public resource by driving a change in the publishing model to open-access publishing and generating tools for mining the scientific literature and for making it comprehensible to the non-specialist
www.plos.org
What is open access?
"free availability on the public internet, permitting and users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited.”
--Budapest Open Access Initiative
www.plos.org
What is an open-access publication?
1. Authors grant right to access and license to copy, use, distribute, transmit and display the work publicly and to make and distribute derivative works for any responsible purpose, subject only to proper attribution of authorship and source.
2. Complete electronic version of the work is deposited in a public repository that seeks to enable open access, unrestricted distribution, interoperability, and long-term archiving.
www.plos.org
Why is open access important?
No financial barrier
Authors reach largest possible audience
Readers (scientists, physicians, educators, public) have access to and the right to use the entire literature
Access to health information as a human right
Allows text and data mining and analysis that is not possible unless full text and data are in one information space
The benefits of research are derived principally from access to research results
www.plos.org
Financing open access: publication as the final step of a research project
Still costs money to produce an article:
mediate peer-review
edit and lay out articles
create PDF and HTML versions
host them on a fast and robust server
deposit them into an open-access archive
a Publication charges per published article
PLoS Biology/PLoS Medicine: $1,500/accepted paper
Many authors already pay (submission charges, page charges, color charges)
Publication charges are a small fraction of the cost that has gone into conducting the research
Open-access publication of results maximizes investment in research
www.plos.org
Given its obvious advantages, why don’t we have open access?
Most publishers do not support it
Not seen as a viable economical model
Not seen as the most profitable model
Scientists are not pushing hard enough for it
Funding agencies and the public are not pushing hard enough for it
Changing the status quo is difficult
… but things are changing
Changes over past 12 months: scientists
Pioneering authors and other supporters vote with their feet and support open-access journals by submitting papers and serving as editors and reviewers
Universities rebel against publishers’ squeeze (UCSF, Cornell)
Open-access summits, sessions, seminars
Remember: scientific publishing is a service industry; scientists need to push for the service they want
www.plos.org
Changes over the past 12 months: funders
Support from funding agencies (HHMI, Wellcome Trust, MPI, DFG, INSERM, CNRS, CAS)
Outside analysis by Wellcome Trust:
“The current market structure does not operate in the long-term interests of the research community.”
NIH is waking up:
“The status quo is not an option.”
  --Elias Zerhouni, August 2004
www.plos.org
Changes over the past 12 months: politicians
UK Parliamentary enquiry:
The House of Commons Science and Technology Committee recommended that all UK higher education institutions establish electronic repositories where their published output can be stored and read, free of charge.
It has also recommended encouraging further experimentation with OA models as one radical long term solution to help improve access to scientific, technical, and medical journals.
EU Parliamentary enquiry under way
Appropriations Committee within the US House of Representatives
Changes over the past 12 months: publishers
Some publishers experiment with open-access (p.e. PNAS, Development, NAR, Nature, Springer)
Other publishers allow free access to more of their content (Nature’s Malaria special)
Elsevier allows personal and institutional archiving (not PDF, not deposition in public repository or wider dissemination )
Cell Press will make archive free
www.plos.org
Changes over the past 12 months: public and media
2003
open access editorials and cover page articles in a few newspapers (NYT, Washington Post)
Harold Varmus and Ira Mellman on Charlie Rose
2004
PLoS founders win Wired Rave Award
Patient advocacy groups start advocating
Open access coverage in news media around the world
Medicine message resonates with pubic
www.plos.org


“Why is it, a growing number of people are asking, that anyone can download medical nonsense from the Web for free, but citizens must pay to see the results of carefully conducted biomedical research that was financed by the taxes. The Public Library of Sciences aims to change that.”

-- Rick Weiss, Washington Post, 5 August 2003
Slide 18
US House of Representatives appropriations bill
Appropriations Committee in the House recommended that from 2005 the National Institutes of Health (NIH) provide free public access via PubMed Central to accepted articles reporting NIH-funded research, at most six months after publication.
Furthermore, if NIH funds were used to pay any costs associated with publication, then access would have to be immediate.
If passed by both houses of Congress, the NIH would be required to indicate by December 1, 2004 how it would implement the policy.
In the meantime…
NIH is holding hearings with various stakeholders
the NIH Guide for Grants and Contracts published a draft policy statement in September for public comment. This draft presents a description of the agency's position and planned actions in the area of public access and is now open for online comments.  In December, NIH will report to Congress on its consultations and proposed next steps
Alliance for Taxpayer Access: http://www.taxpayeraccess.org
Open letters from publishers, some saying they won’t be able to survive (including FASEB and many other societies)
Open letter from 25 Nobel Laureates supporting bill and expressing commitment to open access
An Open Letter to the U.S. Congress
Signed by 25 Nobel Prize Winners
August 26, 2004

Dear Members of Congress:

As scientists and Nobel laureates, we are writing today to express our strong support for the House Appropriations Committee's recent direction to NIH to develop an open, taxpayer access policy requiring that a complete electronic text of any manuscript reporting work supported by NIH grants or contracts be supplied to the National Library of Medicine's PubMed Central.   We believe the time is now for all Members of Congress to support this enlightened policy…

… As the undersigned Nobel Laureates, we are committed to open access.  We ask Congress and NIH to ensure that all taxpayers get their money's worth.  Our investment in scientific research is not well served by a process that limits taxpayer access instead of expanding it.  We specifically ask you to support the House Appropriations Committee language as well as NIH leadership in adopting this long overdue reform.


Peter Agre, Chemistry, 2003
Sidney Altman, Chemistry, 1989
Paul Berg, Chemistry, 1980
Michael Bishop, Physiology or Medicine, 1989
Baruch Blumberg, Physiology or Medicine, 1976
Gunter Blobel, Physiology or Medicine, 1999
Paul Boyer, Chemistry, 1997
Sydney Brenner, Physiology or Medicine, 2002
Johann Deisenhofer, Chemistry, 1988
Edmond Fischer, Physiology or Medicine, 1992
Paul Greengard, Physiology or Medicine, 2000
Leland Hartwell, Physiology or Medicine, 2001
Robert Horvitz, Physiology or Medicine, 2002
Eric Kandel, Physiology or Medicine, 2000
Arthur Kornberg, Physiology or Medicine, 1959
Roderick MacKinnon, Chemistry, 2003
Kary Mullis, Chemistry, 1993
Ferid Murad, Physiology or Medicine, 1998
Joseph Murray, Physiology or Medicine, 1990
Marshall Nirenberg, Physiology or Medicine, 1968
Stanley Prusiner, Physiology or Medicine, 1997
Richard Roberts, Physiology or Medicine, 1993
Hamilton Smith, Physiology or Medicine, 1978
Harold Varmus, Physiology or Medicine, 1989
James Watson, Physiology or Medicine, 1962
Beyond PLoS Biology and PLoS Medicine
Ensure an open access home for every paper worth publishing
Establish top-tier journals in biology and medicine to demonstrate that OAP can work at the top level (example and serious competitors)
Support existing journals who want to adopt OAP
Where necessary, start new journals to serve individual communities and to demonstrate the feasibility of open access (PLoS Community journals and PLoS Reports)
Develop ways to make the scientific literature more useful to scientists and the public
PLoS Community journals
Serve a particular community
Run mainly by Academic Editors
Will demonstrate that publication charges can support a “typical” journal
PLoS will launch at least 3 of these over the next 12 months
Areas: no open-access alternative in sight, community has approached us
www.plos.org
PLoS Reports
Serve specialist communities
Make worthy but in isolation not widely exciting results broadly available
Research that is currently published in specialist journals with limited distribution (or not at all) and would be much more useful when fully searchable and available for systematic reviews/meta-analyses
Examples: genetic association studies, clinical trials with negative results
Editorial model for PLoS Biology and PLoS Medicine
Involves active scientists in editorial decision making
Professional and academic editors work together throughout the reviewing process
Fair, efficient, transparent decisions
www.plos.org
PLoS Biology: www.plosbiology.org
Scope: all areas of basic and applied biology
Top quality papers
those of greatest interest to a specific community (and as such to a wider audience)
interdisciplinary advances
Context
Primers
Synopses
Unsolved Mysteries
Community Pages
PLoS Biology update
Submissions keep going up
Regular coverage in other journals and popular press
User statistics look good, impact factor soon
So far so good… BUT the journal is a means to a larger goal a we need to be more than just another top journal
There is no more excuse!
PLoS Medicine launch: 10/19/04
PLoS Medicine: www.plosmedicine.org
Open access
High quality
Modern
International
Broad (focus on human studies)
No drug advertisements
Research and interpretation
Audience:
Researchers
Physicians
Health policy makers
Medical educators and students
Health care providers
anywhere around the world
-    Patients and their families
An open-access alternative to the existing general medical journals
-- and more
PLoS Medicine: Call for Papers
Significant advances in all disciplines, including epidemiology and public health
Important steps from basic understanding of human health and disease to definitive evidence and practical implementation
Original research, expert commentary, discussion in the context of global health
Rigorous peer-review, rapid publication online and in print
In PubMed and PubMedCentral from day 1
www.plosmedicine.org
PLoS Medicine inaugural issue
(sneak preview)
Authors from five continents
Research on HIV/AIDS, malaria, celiac disease, emphysema, global burden of disease
Debate on routine screening for domestic violence
Julie Gerberding (CDC) on anti-HIV initiatives
Palliative Care in Africa and the Caribbean
Essay on the future of surgical research
Online functionality: movies, quiz, poll, e-letters
www.plosmedicine.org
PLoS Medicine: Call for Action
Submit your best work to PLoS Medicine (or send a presubmission enquiry)
Tell your colleagues about open access and PLoS Medicine
Sign up for updates and e-TOCs
Download materials from our website and distribute them
Write to us at medicine@plos.org
Invite us to talk at your institution or conference
Tell us about research by others that you think is suitable for PLoS Medicine
Share your ideas and help us create a journal that will serve your community
www.plosmedicine.org



There are lots of inequalities in medicine and health care. Access to the latest peer-reviewed research results doesn’t have to be one of them.
Work with us.


  Virginia Barbour    Barbara Cohen
   vbarbour@plos.org    bcohen@plos.org