SALVATORE J. FIDONE
Professor of Physiology
e-mail: s.j.fidone@utah.eduResearch Interests | Publications
Biosketch/Research Interests
Signal transduction and mechanisms of adaptation in mammalian arterial chemoreceptors
Dr. Fidone received his BS degree from Georgetown University (1962) and his Ph.D. degree in Physiology from the State University of New York Upstate Medical Center, Syracuse (1967). After completing an NIH Postdoctoral Fellowship in Physiology, he joined the University of Utah School of Medicine Faculty in 1969. Dr. Fidone has been Professor of Physiology since 1981, and has chaired the department since 1988. He is the recipient of the Jacob K. Javits Neuroscience Investigator Award from the NIH. Dr. Fidone has had extensive peer review experience at the NIH as a member of Neurology A Study Section, and as an ad hoc member of numerous special review panels and site visit teams. He has served on the editorial boards of the Journal of Applied Physiology (1987-97) and Biological Signals and Receptors (1990-2000). Dr. Fidone was elected Honorable Secretary of the International Society for Arterial Chemoreception, and has been an invited speaker at numerous international meetings, symposia and workshops.
Dr. Fidone's research has been continuously funded by NIH for more than three decades. He is the Principal Investigator on an NIH Research Grant (R01) and an NIH Program Project Grant (P01). His research is focused on the mechanisms of sensory transduction and chemical transmission between preneural receptor cells and afferent nerve terminals in mammalian arterial chemoreceptors, which sense blood levels of O2, H+ and CO2 and reflexly adjust cardiopulmonary parameters. A variety of neurochemical, immunocytochemical, electrophysiological and molecular biological techniques are used to elucidate the cellular signaling properties of the organ's chemosensory cells. In addition, altered gene expression and neurotransmitter metabolism in the receptor apparatus accompanying chronic chemostimulation (e.g. chronic hypoxia of high altitude, COPD, asthma, etc.), as well as the trophic interdependencies between preneural receptor cells and their afferent nerve fibers, are examined in these chemosensory receptors.
Publications
(Go to the complete list in PDF Format.)
RESEARCH ARTICLES (1995-current)
Dinger, B., He, L., Chen, J., Stensaas, L. and Fidone, S. Mechanisms of morphological and functional plasticity in the chronically hypoxic carotid body. In: Oxygen Sensing: Responses and Adaptation to Hypoxia, edited by S. Lahiri, G. Semenza and N. Prabhakar. Marcel Dekker, New York, pp. 439-465, 2003.
He, L., Chen, J., Dinger, B., Sanders, K., Sundar, K., Hoidal, J. and Fidone, S. Characteristics of carotid body chemosensitivity in NADPH oxidase-deficient mice. Am. J. Physiol. Cell. Physiol. 282(1): C27-C33, 2002.
Chen, J., He, L., Dinger, B., Stensaas, L. and Fidone, S. Role of endothelin and endothelin A-type receptor in adaptation of the carotid body to chronic hypoxia. Am. J. Physiol. Lung Cell. Mol. Physiol. 282(6): L1314-L1323, 2002.
Sanders, K.A., Sundar, K.M., He, L., Dinger, B., Fidone, S. and Hoidal, J.R. Role of components of the phagocytic NADPH oxidase in oxygen sensing. J. Appl. Physiol. 93(4): 1357-1364, 2002.
Chen, J., He, L., Dinger, B., Stensaas, L. and Fidone, S. Chronic hypoxia up-regulates connexin43 expression in rat carotid body and petrosal ganglia. J. Appl. Physiol. 92: 1480-1486, 2002.
Chen, J., He, L., Dinger, B. and Fidone, S. Stimulus specific signaling pathways in rabbit carotid body chemoreceptors. Neurosci. 95(1): 283-291, 2000.
He, L., Chen, J., Dinger, B. and Fidone, S. Characteristics of carotid body chemosensitivity in the mouse: Baseline studies for future experiments with knockout animals. Adv. Exp. Med. Biol. 475: 607-704, 2000.
Chen, J., He, L., Dinger, B. and Fidone, S. Pharmacological effects of endothelin in rat carotid body: Activation of second messenger pathways and potentiation of chemoreceptor activity. Adv. Exp. Med. Biol. 475: 517-525, 2000.
Chen, J., He, L., Dinger, B. and Fidone, S. Cellular mechanisms involved in rabbit carotid body excitation elicited by endothelin peptides. Respiration Physiol. 121: 13-23, 2000.
He, L., Dinger, B. and Fidone, S. Cellular mechanisms involved in carotid body inhibition produced by atrial natriuretic factor. Am. J. Physiol. Cell Physiol. 278(4): C845-C852, 2000.
Wang, Z.-Z., He, L., Chen, J., Dinger, B., Stensaas, L. and Fidone. S. Protein phosphorylation signaling mechanisms in carotid body chemoreception. Biol. Signals and Receptors 8(6): 366-374, 1999.
Major, J., Dinger, B., Stensaas, L.J., Wang, Z.-Z. and Fidone, S. A quantitative immunocytochemical approach to the analysis of type I cells in the cat carotid body. Biol. Signals and Receptors 8: 375-381, 1999.
Wang, Z.-Z., Dinger, B., Fidone, S.J. and Stensaas, L.J. Changes in tyrosine hydroxylase and substance P immunoreactivity in the cat carotid body following chronic hypoxia and denervation. Neurosci. 93(4): 1273-1281, 1998.
Chen, J., Dinger, B. and Fidone, S.J. cAMP production in rabbit carotid body: The role of adenosine. J. Appl. Physiol. 82: 1771-1775, 1997.
Obeso, A., Gomez-Nino, A., Almaraz, L., Dinger, B., Fidone, S. and Gonzalez, C. Evidence for two types of nicotinic receptors in the cat carotid body chemoreceptor cells. Brain Res. 754: 298-302, 1997.
Chen, J., Gomez-Nino, A., Gonzalez, C., Dinger, B. and Fidone, S. Stimulus-specific mobilization of dopamine and norepinephrine stores in cat carotid body. J. Auton. Nerv. Syst. 67: 109-113, 1997.
He, L., Chen, J., Dinger, B., Stensaas, L. and Fidone, S. Endothelin modulates chemoreceptor cell function in mammalian carotid body. Adv. Exp. Med. Biol. 410: 305-311, 1996.
Chen, J., Swensen, J., Dinger, B. and Fidone, S. Evaluation of gene expression in the rat carotid body using the differential display technique. Adv. Exp. Med. Biol. 410: 119-125, 1996.
Wang, Z.Z., Stensaas, L., Dinger, B.G. and Fidone, S.J. Nitric oxide mediates chemoreceptor inhibition in the cat carotid body. Neurosci. 65: 217-229, 1995.
Wang, Z.Z., Dinger, B.G., Stensaas, L.J. and Fidone, S.J. The role of nitric oxide in carotid chemoreception. Biol. Signals 4: 109-116, 1995.
Chen, J., Dinger, B. and Fidone, S.J. Second messenger regulation of tyrosine hydroxylase gene expression in rat carotid body. Biol. Signals 4: 227-285, 1995.
REVIEWS (1995-current)
Fidone, S., Dinger, B. and Gonzalez, C. Carotid body, mammalian. In: Encyclopedia of Neuroscience, eduted by G. Adelman and B.H. Smith. Elsevier Science B.V. (Third Edition; Chapter Revision) (in press).
Fidone, S., Dinger, B. and Gonzalez, C. Carotid body, mammalian. In: Encyclopedia of Neuroscience, edited by G. Adelman and B.H. Smith. Elsevier Science B.V. (Second Edition; Chapter Revision) pp. 314-316, 1999.
Fidone, S., Dinger, B. and Gonzalez, C. Cellular mechanisms of peripheral chemoreceptor function. In: The Lung: Scientific Foundations, edited by R.G. Crystal, J.G. West, E.R. Weibel and P.J. Barnes. Raven Press: New York (Second Edition), pp. 1725-1746, 1997.
Gonzalez, C., Dinger, B. and Fidone, S. Functional significance of chemoreceptor cell neurotransmitters. In: The Carotid Body Chemoreceptors, edited by C. Gonzalez. R.G. Landes Medical Publishers. Distribution: Springer-Verlag: Heidelberg, Germany, pp. 47-64, 1997.
Almaraz, L., Wang, Z.Z., Dinger, B. and Fidone, S. Neurotransmitter mediation of carotid chemoreceptor efferent inhibition. In: The Carotid Body Chemoreceptors, edited by C. Gonzalez. R.G. Landes Medical Publishers. Distribution: Springer-Verlag: Heidelberg, Germany, pp. 147-158, 1997.
Gonzalez, C., Dinger, G.B. and Fidone, S.J. Mechanisms of carotid body chemoreception. In: The Lung Biology in Health and Disease, Vol. X "The Regulation of Breathing," Claude Lenfant, executive editor, Jerome A. Dempsey and Allan I. Pack, editors, Marcel Dekker, Inc.: New York, pp. 391-471, 1995.
BOOKS, MONOGRAPHS, JOURNAL SPECIAL EDITIONS (1995-current)
Signal Transduction in Chemosensitive Receptor Cells, edited by S.J. Fidone and B.W. Ache. Biological Signals and Receptors (Special Edition), Vol. 8, 1999.
Cardiovascular Sciences: Recent Advances, edited by Y.S. Chan, T.M. Wong and S.J. Fidone, Biological Signals (Special Edition), Vol. 4, No. 3 (pp. 105-194), 1995.
Recent Advances in Carotid Chemotransduction, edited by S.J. Fidone. Biological Signals (Special Edition), Vol. 4, No. 5 (pp. 241-310), 1995.
ABSTRACTS (1999-current)
Chen, J., Dinger, B., Stensaas, L. and Fidone, S. Effect of endothelin-A/B receptor antagonist bosentan on chronic hypoxia (CH)-induced tissue remodeling in rat carotid body. Program No. 355.3. Abstract Viewer/Itinerary Planner. Washington DC: Society for Neuroscience, 2002.
He, L., Dinger, B., Sanders, K., Sundar, K., Hoidal, J. and Fidone, S. Functional properties of carotid body chemosensory type I cells in mice lacking the P47 cytosolic component of NADPH oxidase. Program No. 355.3. Abstract Viewer/Itinerary Planner. Washington DC: Society for Neuroscience, 2002.
Chen, J., Dinger, B., Stensaas, L. and Fidone, S. Effect of endothelin-A/B receptor antagonist bosentan on chronic hypoxia (CH)-induced tissue remodeling in rat carotid body. Proceedings of the XRth International Symposium on Arterial Chemoreception, Lyon, France, 2002 (in press).
He, L., Chen, J., Dinger, B., Sanders, K., Sundar, K., Hoidal, J. and Fidone, S. Evaluation of carotid body chemoreceptor function in mice deficient in a cytosolic component of NADPH oxidase. Proceedings of the XVth International Symposium on Arterial Chemoreception, Lyon, France, 2002 (in press).
Chen, J., Dinger, B., Stensaas, L. and Fidone, S. Effect of endothelin-A/B receptor antagonist bosentan on chronic hypoxia (CH)-induced tissue remodeling in rat carotid body. Soc. Neurosci. Abstr. 2002 (in press).
He, L., Dinger, B., Sanders, K., Sundar, K., Hoidal, J. and Fidone, S. Functional properties of carotid body chemosensory type I cells in mice lacking p47 cytosolic component of NADPH oxidase. Soc. Neurosci. Abstr. 2002 (in press).
He, L., Dinger, B., Sanders, K., Sundar, K., Hoidal, J. and Fidone, S. Evaluation of hypoxic ventilatory response (HVR) and carotid body chemoreceptor function in mice deficient in a cytosolic component of NADPH oxidase. FASEB Journal 16: A814, 2002.
Chen, J., Dinger, B., Stensaas, L. and Fidone, S. Effect of an endothelin A-type receptor antagonist on chronic hypoxia (CH)-induced tissue remodeling in rat carotid body. FASEB Journal 16: A66, 2002.
He, L., Chen, J., Dinger, B. and Fidone, S. Chemical synaptic transmission in the chronically hypoxic rat carotid body. Soc. Neurosci. Abstr. 287.12, 2001.
He, L., Dinger, B., Powell, F. and Fidone, S. Evaluation of carotid body chemoreceptor activity elicited by doxapram after a 48 hour hypoxic exposure. FASEB Journal 15: A153, 2001.
Chen, J., Dinger, B., Stensaas, L. and Fidone, S. Involvement of vascular endothelial growth factor (VEGF) in carotid body vascular remodeling induced by chronic hypoxia. FASEB Journal 15: A164, 2001.
Dinger, B., He, L., Chen, J., Stensaas, L. and Fidone, S. The effect of chronic hypoxia on purinergic synaptic transmission in rat carotid body. FASEB Journal 15: A153, 2001.
Chen, J., He, L., Dinger, B. and Fidone, S. Physiological adaptation of chemoafferent neurons induced by chronic hypoxia. FASEB Journal 14: A393, 2000.
He, L., Chen, J., Dinger, B. and Fidone, S. Altered cholinergic chemotransmission in rat carotid body following chronic hypoxia. FASEB Journal 14: A393, 2000.
Chen, J., He, L., Dinger, B., Stensaas, S. and Fidone, S. Up-regulation of connexin-43 and altered chemical synaptic transmission in chronically hypoxic rat carotid body. Soc. Neurosci. Abstr. 26: 1708, 2000.
Dinger, B., Chen, J., He, L. and Fidone, S. Endothelin is involved in the increased chemosensitivity of the chronically hypoxic rat carotid body. FASEB Journal 13: A1093, 1999.
He, L., Chen, J., Dinger, B. and Fidone, S. Characteristics of carotid body chemosensitivity in the mouse: Baseline studies for future experiments with knockout animals. Proceedings of the XIVth International Symposium on Arterial Chemoreception, Philadelphia, Pennsylvania, 1999.
Chen, J., He, L., Dinger, B. and Fidone, S. Dynamics of neuroactive and vasoregulatory agents in the carotid body. Proceedings of the XIVth International Symposium on Arterial Chemoreception, Philadelphia, Pennsylvania, 1999.
Chen, J., He, L., Dinger, B., Sanders, K., Hoidal, J. and Fidone, S. Carotid body function in NADPH oxidase-deficient mice. Soc. Neurosci. Abstr. 25: 934, 1999.
He, L., Dinger, B. and Fidone, S. Effect of cell permeant cyclic GMP (cGMP) analogs on potassium and calcium currents in carotid body chemosensory type I cells. Soc. Neurosci. Abstr. 25: 934, 1999.
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