H. STEVE WHITE
Professor of Pharmacology and Toxicology
e-mail: Steve.White@hsc.utah.eduEducation | Research Interests | Publications
Education
Baccalaureate Degree: 1977, Idaho State University, Pharmacy.
Advanced Degrees: M.S., 1979, Idaho State University, Pharmacology
Ph.D., 1984, University of Utah, Pharmacology
Research Interests
Neuropharmacology; anticonvulsant drug mechanisms; neuron-glia interactions.
Dr. White is the principal investitgator and principal scientist working with the NIH sponsored Anticonvulsant Drug Development Program established in 1975 to identify novel anticonvulsant drugs using established animal models of epilepsy. His research is focused on understanding the factors which contribute to the initiation, propagation and amelioration of seizure activity. Dr. White utilizes a variety of in vivo and in vitro model systems to identify and characterize the mechanisms of action of existing and newly designed anticonvulsant drugs. In addition, his work has focused on understanding the pathophysiology of audiogenic seizures in the genetically audiogenic susceptible Frings mouse. A greater understanding of the factors that contribute to seizures and of the mechanisms through which drugs block seizures should lead to the design of more efficacious and less toxic anticonvulsant drugs for the treatment of epilepsy.
Publications
(Go to the complete list in PDF Format.)
Walker, M.C., White, H.S. and Sander, J.W.A.S. Disease modification in partial epilepsy. Brain 125: 1937-1950, 2002.
Rho, J.M., Anderson, G.D., Donevan, S.D. and White, H.S. Acetoacetate, acetone and dibenzylamine (a contaminant in 1- (+)-beta-hydroxybutyrate) exhibit direct anticonvulsant actions in vivo. Epilepsia 43(4): 358-361, 2002.
Isoherranen, N., White, H.S., Finnell, R.H., Yagen, B., Woodhead, J.H., Bennett, G.D., Wilcox, K.S., Barton, M.E. and Bialer, M. Anticonvulsant profile and teratogenicity of N- methyl-tetramethylcyclopropyl carboxamide: A new antiepileptic drug. Epilepsia 43(2): 115-126, 2002.
Barton, M.E., Klein, B.D., Wolf, H.H. and White, H.S. Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy. Epilepsy Res. 47: 217-227, 2001.
Skradski, S.L., Clark, A.M., Jiang, H., White, H.S., Fu, Y.-H. and Ptacek, L.J. A novel gene causing a Mendelian audiogenic mouse epilepsy. Neuron 31: 537-544, 2001.
Isoherranen, N., Woodhead, J.H., White, H.S. and Bialer, M. Anticonvulsant profile of valprocemide (TV1901): a new antiepileptic drug. Epilepsia 42(7): 831-836, 2001.
Frankel, W.N., Taylor, L., Beyer, B., Tempel, B.L. and White, H.S. Electroconvulsive thresholds of inbred mouse strains. Genomics 74(3): 306-312, 2001.
Moe, S.T., Smith, D.L., DelMar, E.G., Shimizu, S.M., Van Wagenen, B.C., Balandrin, M.F., Chien, Y.E., Raszkiewicz, J.L., Artman, L.D., White, H.S. and Mueller, A.L. Chiral synthesis and pharmacological evaluation of NPS 1407: a potent, stereoselective NMDA receptor antagonist. Bioor. Med. Chem. Lett. 10(21): 2411-2415, 2000.
Lian, H., Steiner, S.S., Sofia, R.D., Woodhead, J.H., Wolf, H.H., White, H.S., Shen, G.S., Rhodes, C.A. and McCabe, R.T. A self-complementary, self-assembling microsphere system: Application for intravenous delivery of the antiepileptic and neuroprotectant compound felbamate. J. Pharm. Sci., 89(7): 867-875, 2000.
Skradski, S. and White, H.S. Topiramate blocks kainate-evoked cobalt influx into cultured neurons. Epilepsia 41(Suppl. 1): S45-S47, 2000.
White, H.S., Brown, S.D., Woodhead, J.H., Skeen, G.A. and Wolf, H.H. Topiramate modulates GABA-evoked currents in murine cortical neurons by a nonbenzodiazepine mechanism. Epilepsia 41(Suppl. 1): S17-S20, 2000.
Klein, B.D., White, H.S. and Callahan, K.S. Cytokine and intracellular signaling regulation of tissue factor expression in astrocytes. Neurochemistry Int. 36: 441-449, 2000.
White, H.S., McCabe, R.T., Armstrong, H., Donevan, S., Cruz, L.J., Abogadie, F.C., Torres, J., Rivier, J.E., Paarman, I., Hollmann, M. and Olivera, B.M. In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snal Conus radiatus. J. Pharmacol. Exp. Ther. 292: 425-432, 2000.
Falch, E., Perregaard, J., Frolund, B., Sokilde, B., Burr, A., Hansen, L.M., Frydenvang, K., Brehm, L., Bolvig, T., Larsson, O.M., Sanchez, C., White, H.S., Schousboe, A. and Krogsgaard-Larsen, P. Selective inhibitors of glial GABA uptake: Synthesis, absolute stereochemistry and pharmacology of the enantiomers of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2- benzisoxazole (Exo-THPO) and analogues. J. Med. Chem. 42(26): 5402-5414, 1999.
Hanson, G.R., Jensen, M., Johnson, M. and White, H.S. Distinct features of seizures induced by cocaine and amphetamine analogs. European J. Pharmacol. 377(2-3): 167-173, 1999.
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