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What are the differences between fatty acid synthesis and beta-oxidation?
The two processes are superficially the reverse of one another. There are, however, several important differences, allowing for differential control, with one process inhibited while the other is stimulated.
Synthesis | Beta-Oxidation | |
---|---|---|
cytoplasm | mitochondria | |
multifunctional enzyme | separate enzymes | |
NADPH | NAD and FAD | |
Energy
requirement: 49 ATP equivalents |
Energy
yield: 33 ATP equivalents |
|
Regulation: Acetyl CoA carboxylase |
Regulation: Acetyl CoA availability |