Diseases Associated with Hyperbilirubinemia

Several diseases are associated with hyperbilirubinemia. Direct and indirect bilirubin values are used in the differential diagnosis of hyperbilirubinemia.

Hyperbilirubinemia could be caused by

Here is a schematic diagram that represents normal bilirubin metabolism. Use this to compare with various abnormal states described below. Clicking on the diagrams will reveal larger versions of them.

Here are some examples of diseases in which hyperbilirubinemia is observed.

Hemolytic jaundice

Gilbert's disease

Physiological jaundice and Crigler-Najjar syndrome

Dubin-Johnson syndrome

Biliary obstruction

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Last modified 1/5/95