Hodgkin Lymphoma
Hodgkin lymphoma (HL), formerly called Hodgkin disease (HD) may respond well to therapy. Thus, it is important to determine the stage of the disease and the histologic type of HD in order to provide the most appropriate therapy. The first four types listed in the table below are "classical HL" and have Reed-Sternberg cells that immunohistochemically are positive for CD15 and CD30 but negative for CD45.
Nodular lymphocyte-predominant HL has RS cells that are CD20 positive but CD15 and CD30 negative, like B cells. |
Hodgkin Lymphoma - Classification
| Type | Histologic Features | Frequency | Prognosis
|
Nodular sclerosis | Bands of fibrosis, lacunar cells | Most frequent type (60-80%), more common in women | Good, most are stage I or II
|
Mixed cellularity | Composed of many different cells | Most frequent in older persons, second most frequent overall (15-30%) | Fair, most are stage III
|
Lymphocyte rich | Mostly reactive lymphocytes and many Reed-Sternberg cells | Uncommon (5%). Older adults | Good to excellent
|
Lymphocyte depletion | Many Reed-Sternberg cells and variants | Rare (<1%) | Poor, most are stage III or IV
|
Nodular lymphocyte-predominant | Mostly B-cells and few Reed-Sternberg variant cells | Uncommon (5%) | Good, most are stage I or II
|