| Non-Hodgkin's Lymphomas
|
|---|
| Type | Histologic Features | Immunogenetics | Clinical Features
|
| Small Lymphocytic Lymphoma
| Small and well-differentiated B lymphocytes, with diffuse effacement of nodal architecture and no follicles
| CD19, 5; Bcl-2 and Bcl-6 expression
| Seen in older adults, it is essentially the solid tissue (lymph nodal) component of chronic lymphocytic leukemia; disease tends to be generalized but with indolent course and prolonged survival; some may transform to more aggressive lymphomas
|
| Follicular Lymphoma (predominantly small cell)
| Nodal architecture is effaced by monotonous, crowded follicles composed of monomorphous small cleaved B-lymphocytes
| CD19, 20, 79a; t(14:18); Bcl-2 expression
| Most common type, seen in adults, often involves multiple lymph nodes, course is indolent, with prolonged survival, though some may transform to a large cell lymphoma
|
| Diffuse Large B-cell Lymphoma
| Cells are large, with prominent nucleoli and abundant cytoplasm and many mitoses. Most are B-cell, but 20% are T-cell phenotype
| CD19, 20, 79a; some have t(14;18); some have Bcl-2 and Bcl-6 expression; linked to EBV infection; negative TdT
| Though often localized, they tend to be aggressive extranodal masses; seen in adults and children, can be seen in HIV infection
|
| Burkitt Lymphoma
| Intermediate sized B-lymphocytes (small-noncleaved cells)
| CD10, 19, 20, 79a; t(8:14) is characteristic; African form linked to EBV infection; negative TdT
| Endemic in Africa with mandibular and abdominal involvement; sporadic elsewhere with abdominal involvement; affects mainly children and young adults
|
| High-grade B-cell Lymphoma (small non-cleaved) Burkitt-like Lymphoma
| Intermediate sized B-lymphocytes (small non-cleaved cells)
| CD19, 20
| Sporadic; may be seen with HIV infection
|
| Precursor T or B-cell Lymphoblastic Lymphoma/Leukemia (Lymphoblastic Lymphoma)
| Intermediate sized lymphocytes in a diffuse pattern
| B-cells are CD19, 20, sometimes CD10; T-cells are CD3 and 8; all are TdT positive
| Seen in children and adolescents; T-cell type often in mediastinum; very aggressive and can progress to acute lymphocytic leukemia
|
| Mantle Cell Lymphoma
| Small to medium sized B cells
| CD 19, 20, 43; t(11;14); Bcl-1 (Cyclin D1) expression
| Seen in adults in middle age; often advanced at diagnosis and may be extranodal, including multifocal submucosal nodules in bowel
|
| Marginal Zone Lymphoma
| Small to medium sized B cells
| CD19, 20, 79a; negative CD5 and 10
| Seen in middle aged adults; typically arises in areas of immune activation (Hashimoto thyroiditis, Sjogren syndrome, Helicobacter pylori gastritis); similar lesions asociated with mucosal lymphoid tissue are called MALTomas (mucosa-associated lymphoid tissue tumors); may transform to diffuse large B-cell lymphoma
|
