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Sexual Differentiation : Klinefelter's Syndrome

Males with Klinefelter's Syndrome have an XXY karyotype, long extremities, and a eunuchoidal appearance with gynecomastia. The testicular biopsy demonstrates hyalinization of seminiferous tubules and Leydig cell hyperplasia.

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Klinefelter's Syndrome. Males with an XXY karyotype characteristically have long extremities, a eunuchoidal habitus, and gynecomastia.
Credits: Adapted with permission from Grumbach M.M. and Conte F.A., Disorders of Sexual Differentiation. In Williams R.H. ed, Textbook of Endocrinology, W. B. Suanders Co., Philadelphia, 1981, p 451.