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V. De novo Synthesis of Fatty Acids

Overview Overview: Tissue locations Overview: Reaction sum     Enzymes and Isolated Reactions Enzymes and Isolated Reactions: Acetyl CoA carboxylase Enzymes and Isolated Reactions: Activities of FA Synthase Enzymes and Isolated Reactions: Characteristics of Fatty Acyl Synthase     Acetyl Groups and Reducing Equivalents     Previous Page Next Page

Enzymes and Isolated Reactions: Acetyl CoA carboxylase

Acetyl CoA carboxylase has three important features.

  1. It contains the prosthetic group, biotin.
  2. The carboxylation reaction is driven to completion by hydrolysis of ATP.
  3. The enzyme catalyzes the rate-limiting reaction for fatty acid synthesis, and is under tight short-term control.

To summarize, it is controlled both allosterically (citrate, palmitoyl CoA) and by covalent modification (phosphorylation/dephosphorylation).


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