VII. Mobilization and Transport of Adipose Fatty Acid
Adipocytes release nonesterified fatty acids.
Nonesterified fatty acid release from the adipocytes is initiated by the
action of hormone sensitive lipase (HSL), which begins to hydrolyze the stored triglyceride.
The final products of triacylglycerol hydrolysis are glycerol and
nonesterified fatty acids.
- HSL is activated by epinephrine, norepinephrine, ACTH and
glucagon, acting via phosphorylation of the enzyme.
- It is inhibited by insulin.
Nonesterified fatty acids are bound to serum albumin for transport to other
they are used.
- Major target tissues are muscle and liver.
- At the target cells nonesterified fatty acids are taken up
passively. Within the target cells they are bound to fatty acid
binding protein. Next they must be activated.