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V. De novo Synthesis of Fatty Acids

Overview Overview: Tissue locations Overview: Reaction sum     Enzymes and Isolated Reactions Enzymes and Isolated Reactions: Acetyl CoA carboxylase Enzymes and Isolated Reactions: Activities of FA Synthase Enzymes and Isolated Reactions: Characteristics of Fatty Acyl Synthase     Acetyl Groups and Reducing Equivalents     Previous Page Next Page

Enzymes and Isolated Reactions

Acetyl CoA carboxylase catalyzes the reaction:
acetyl CoA + HCO3- + ATP -> malonyl CoA + ADP + Pi
Six molecules of malonyl CoA and one molecule of acetyl CoA then interact sequentially with fatty acid synthase to yield the final product, palmitate.
Fatty acid synthase is a multifunctional enzyme with seven activities.


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