V. De novo Synthesis of Fatty Acids
Enzymes and Isolated Reactions
Acetyl CoA carboxylase catalyzes the reaction:
acetyl CoA + HCO3- + ATP -> malonyl CoA
+ ADP + Pi
Six molecules of malonyl CoA and one molecule of acetyl CoA then interact sequentially with fatty acid synthase to yield the final product, palmitate.
Fatty acid synthase is a multifunctional enzyme with seven