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VIII. Fatty Acid Activation and Transport into the Mitochondria

Overview Activation Transport Transport and Regeneration     Previous Page Next Page


Fatty acids are activated by fatty acyl CoA synthetase.

The reaction:

R-COOH + CoASH + ATP <--> R-CO-SCoA + AMP + PPi

The subsequent hydrolysis of PPi draws the reaction in the forward direction, maintaining a low cytosolic free fatty acid concentration:

PPi + H2O --> 2 Pi

The reaction occurs in the endoplasmic reticulum and the outer mitochondrial membrane.


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