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IX. Mitochondrial beta-oxidation

Overview     Four enzymes and reactions Four enzymes and reactions: Dehydrogenation Four enzymes and reactions: Hydration Four enzymes and reactions: 2nd dehydrogenation Four enzymes and reactions: Thiolytic cleavage     Complete beta-oxidation of palmitoyl CoA     Additional Enzymes Additional Enzymes: Enoyl CoA Additional Enzymes: trans- vs cis Additional Enzymes: Propionyl CoA     Summary     Previous Page Next Page


Beta-oxidation is the process by which long chain fatty acyl CoA is degraded. The products of beta-oxidation are:

The overall reaction, using palmitoyl CoA (16:0) as a model substrate:

7 FAD + 7 NAD+ + 7 CoASH + 7 H2O +
H(CH2CH2)7CH2CO-SCoA -->
8 CH3CO-SCoA + 7 FADH2 + 7 NADH + 7 H+

Fate of acetyl CoA

Fate of the FADH2 and NADH + H+


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