Dermatology Nitrous Oxide / Bites Nitrous Oxide--Potential Side Effects

Nitrous oxide, mechanism of action within the brain

John L. Bezzant,M.D.

Nitrous oxide seems to exert its effect in the brain via release of endorphin. In my experience, if the patient is taking opiates, that the concentration of nitrous oxide I use (50 volume %) generally produces no apparent sedation and analgesia.