Clinical problems found with long term use or abuse of nitrous oxide
Dermatology Nitrous Oxide / Bites Nitrous Oxide--Potential Side Effects


Neurological Symptoms in 15 Patients with Nitrous Oxide Myeloneuropathy
 
  Number of patients
Symptoms Initial
symptoms
Later
symptoms

Lhermitte's Disease 0 12
Numbness, paresthesias, or clumsiness of hands 7 13
Numbness or paresthesias in legs 7 15
Numbness of trunk 0 10
Impairment of equilibrium or gait 3 12
Inability to work unassisted 0 7
Impotence 0 7
Impairment of sphincter 0 4
Altered mood or difficulty in thinking 0 7
Dysarthria 0 2
Impairment of smell or taste 0 1
Relapsing course - 6
Inability to work - 10
*From Layzor (1978)